Dendritic cells change IL-27 production pattern during childhood

Butyrate increases IL-23 production by stimulated dendritic cells.

The gut microbiota is essential for the maintenance of intestinal immune homeostasis and is responsible for breaking down dietary fiber into short-chain fatty acids (SCFAs). Butyrate, the most abundant bioactive SCFA in the gut, is a histone deacetylase inhibitor (HDACi), a class of drug that has potent immunomodulatory properties. This characteristic of butyrate, along with our previous discov...

Dendritic Cells Amplifies IL-17 Production Increased Osteopontin Expression in

IL-27 Promotes IL-10 Production by Effector

Dendritic Cells Regulatory Functions of Liver Plasmacytoid Upregulation of B7-H1 Mediate Immune IL-27 Production and STAT3-Dependent

Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells

Interleukin (IL)-4 is known to be the most potent cytokine that can initiate Th2 cell differentiation. Paradoxically, IL-4 instructs dendritic cells (DCs) to promote Th1 cell differentiation. We investigated the mechanisms by which IL-4 directs CD4 T cells toward the Th1 cell lineage. Our study demonstrates that the IL-4-mediated induction of Th1 cell differentiation requires IL-10 production b...